Protein structure determination using a combination of cross-linking, mass spectrometry, and molecular modeling.
نویسندگان
چکیده
Cross-linking in combination with mass spectrometry can be used as a tool for structural modeling of protein complexes and multidomain proteins. Although cross-links represent only weak structural constraints, the combination of a limited set of experimental cross-links with molecular docking/modeling is often sufficient to determine the structure of a protein complex or multidomain protein at low resolution.
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ورودعنوان ژورنال:
- Methods in molecular biology
دوره 426 شماره
صفحات -
تاریخ انتشار 2008